I had a problem that sounds similar to what you are experiencing, I would double click on an item in my xlate but it appeared nothing would happen.
In my case the properties window was popping up but it was off my desktop — when I switch to a higher resolution I could see the window on the far right of my screen.
I am using version 5.3 so it may vary but here is one way to fix this:
Look in the folder C:quovadxqdx5.3integratorclient (or wherever you installed quovadx)
There is a file named client.ini
Open this up in notepad and look for a section with your username in it similar to this:
[user_yourusername_xlate_config]
On my computer it looks like this:
[user_davdil_xlate_config]
property_dlg_pos=48 197
property_dlg_size=827 409
The property_dlg_pos controls the screen position (with coordinate 0,0 in the upper left of the screen). The property_dlg_size controls the size of the property dialog window.
If the property_dlg_pos coordinates are very large, or even negative the window is probably off the visible screen.
Change the values for the property_dlg_pos to move the window to where you can see it.
I would backup the client.ini file before making any changes just in case something goes wrong
This may not have anything to do with the problem you are seeing but thought I would toss it out there just in case